I'm reading
Monday Starts on Saturday by
Arkady and Boris Strugatsky, but only intermittently. I keep it in the car and pull it out when I am waiting for someone, usually my wife. Today I'm reading along and on page 100 I find this sentence:
Singing and talking strains appeared, and the descendants of the most ancient species now fed exclusively on a mixture of pyrethrum and chlorophene.
They're talking about bats, the book is mostly a bunch of confused nonsense, so 'pyrethrum and chlorophene' could be just words the authors invented, but let's see what our lord and master Google has to say.
Pyrethrum refers to certain perennial daisy-like plants—most notably Dalmatian chrysanthemum and painted daisy — belonging to the aster family. These plants are famous for producing pyrethrins, natural organic compounds in their seed cases and flower heads that act as potent, fast-acting natural insecticides.
Cychlorphine (often referred to or misspelled as chlorophene) is an emerging, highly potent synthetic opioid belonging to a class of compounds known as "orphines".
Key Facts About Cychlorphine
- Potency: Laboratory and pharmacological data indicate cychlorphine is potentially up to 10 times more potent than fentanyl, making even microscopic amounts life-threatening.
- Origin: The compound was originally described in 1960s pharmaceutical research (such as a 1967 patent by Janssen Pharmaceuticals), but it was never approved for human use or medical application.
- Illicit Supply: It has surfaced in the illicit drug market mixed into or masquerading as other substances, including heroin, cocaine, methamphetamine, and counterfeit prescription pills.
- Detection Challenges: Cychlorphine is not detectable by standard fentanyl test strips or routine hospital opioid urine screens, requiring specialized laboratory toxicology testing to confirm.
- Overdose Reversal: While naloxone (Narcan) is still the primary emergency treatment, severe or deep respiratory depression from cychlorphine may require multiple doses of naloxone.
Google's first link goes to the
National Library of Medicine page about Chlorophene where we find:
3.2.1 Physical Description
Ortho-benzyl-para-chlorophenol appears as white to light tan or pink flakes or white crystals. Insoluble in water. Slight phenolic odor. (NTP, 1992)
How do you know what it smells like, since inhaling a microscopic amount could kill you?
7.3 Reported Fatal Dose
3. 3= MODERATELY TOXIC: Probable oral lethal dose (human) 0.5-5 g/kg, between 1 oz and 1 pint for 70 kg person (150 lbs).
On one hand even microscopic amounts can be life-threatening and on the other a fatal dose could be as much as a pint. Something does not compute. There's probably some footnote in there somewhere that explains the discrepancy, but I ain't a chemist.
Anyway, looking over the page about Chlorophene at the National Library of Medicine (it's a very long, very sparse page), I found a surprisingly long list of manufacturers (67) of this drug. Being on the list may not mean anything other than they have the formula for the drug on their books.
| National Library of Medicine | | |
| Number | Company Name | PubChem SID | Purchasable Chemical |
| 51 | 001Chemical | 439988649 | DY510814 |
| 28 | 10X CHEM | 491495581 | TX000R5M |
| 9 | A2B Chem | 443817784 | AA33494 |
| 27 | AA BLOCKS | 374150557 | AA000PX6 |
| 23 | AbaChemScene | 463562650 | CS-0066335 |
| 62 | abcr GmbH | 316400672 | AB125458 |
| 2 | Accel Scientific | 507558058 | EC000S5Q |
| 15 | Accela ChemBio Inc. | 517727033 | SY048947 |
| 63 | Achemtek | 508824336 | MSK2543 |
| 29 | Acmec Biochemical | 485434378 | B60870 |
| 55 | Activate Scientific | 442122558 | AS140265 |
| 33 | AiFChem an XtalPi Company | 508424768 | ACXEQC261 |
| 57 | AKos Consulting & Solutions | 105981470 | AKOS001434264 |
| 64 | Aladdin Scientific | 504751675 | B152826 |
| 19 | Alfa Chemistry | 486317154 | APS120321 |
| 19 | Alfa Chemistry | 486412739 | ACM120321 |
| 19 | Alfa Chemistry | 527715894 | PI120321 |
| 47 | Ambeed | 377506182 | A335646 |
| 1 | Angene Chemical | 207118804 | AGN-PC-0JK8JM |
| 1 | Angene Chemical | 521716097 | AG000PZY |
| 6 | AppChem | 503289682 | AI33494 |
| 12 | AstaTech Inc. | 458781152 | D88696 |
| 66 | BenchChem | 445697205 | B1669242 |
| 8 | Biorbyt | 516470329 | orb1909603 |
| 8 | Biorbyt | 525002152 | orb3139480 |
| 8 | Biorbyt | 528787049 | orb1940359 |
| 31 | BLD Pharm | 377352155 | BD17759 |
| 5 | BOC Sciences | 341110978 | 120-32-1 |
| 5 | BOC Sciences | 488319150 | NP2809 |
| 11 | CAPOT | 152240834 | 15819 |
| 50 | CATO Research Chemicals Inc. | 513788494 | CCPD100935 |
| 16 | Chem-Space.com Database | 434441788 | CSSB00000211996 |
| 44 | ChemoSapiens | 514148688 | 314486 |
| 46 | CHIRALEN | 532080698 | C965305-CT |
| 61 | Clinivex | 497168154 | RCLST000573 |
| 10 | Cooke Chemical Co. Ltd | 478258996 | A1588712 |
| 49 | CymitQuimica | 470236302 | CQ_120-32-1 |
| 41 | DC Chemicals | 439515919 | DC33723 |
| 48 | Debye Scientific Co. Ltd | 387058932 | DB-041547 |
| 22 | DempoChem | 523957873 | 120-32-1 |
| 67 | DSL Chemicals | 475715860 | C004749 |
| 52 | eMolecules | 490660654 | 519767 |
| 26 | Enamine | 473167828 | EN300-21338 |
| 26 | Enamine | 475368553 | Z104495406 |
| 26 | Enamine | 521602300 | EBC-332138 |
| 43 | eNovation Chemicals | 496389750 | Y1466745 |
| 17 | Finetech Industry Limited | 164796459 | FT-0611303 |
| 25 | Fluorochem | 527865544 | F320130 |
| 20 | Hairui Chemical | 375645451 | HR100007 |
| 32 | Hangzhou APIChem Technology | 92710176 | AC-10752 |
| 24 | J&H Chemical Co. ltd | 469489269 | JH619864 |
| 24 | J&H Chemical Co. ltd | 477518052 | JH486095 |
| 30 | Key Organics/BIONET | 442079612 | BS-20052 |
| 21 | LGC Standards | 340508030 | DRE-C10572000 |
| 21 | LGC Standards | 485254505 | TRC-C375000 |
| 21 | LGC Standards | 495993976 | TRC-C375000-10G |
| 18 | Mcule | 167376482 | MCULE-8594187019 |
| 45 | MedChemexpress MCE | 488241725 | HY-118547 |
| 7 | MicroCombiChem GmbH | 483477734 | MCC10433 |
| 42 | MolCore | 405441982 | MC510814 |
| 42 | MolCore | 446214617 | DY510814 |
| 34 | Molport | 87623734 | MolPort-000-145-915 |
| 35 | MuseChem | 355154639 | R056891 |
| 4 | Oakwood Products | 312606154 | 320130 |
| 13 | Pi Chemicals | 322089174 | PI-32433 |
| 60 | Quality Control Solutions | 522887188 | RG-A261687 |
| 14 | RR Scientific | 472449995 | R004004 |
| 65 | Sigma-Aldrich | 24879046 | 548618_ALDRICH |
| 39 | Sinfoo Biotech | 404796854 | S018324 |
| 53 | Smolecule | 438454079 | S524058 |
| 59 | Starshine Chemical | 464752353 | starbld0586441 |
| 40 | SynHet - Synthetic Heterocycles | 506016282 | CAS-120-32-1 |
| 38 | TargetMol | 494442850 | T25266 |
| 36 | TCI (Tokyo Chemical Industry) | 87563799 | B0812 |
| 56 | Thermo Fisher Scientific | 459260104 | GID_900000007869679 |
| 3 | TimTec | 124530890 | ST029301 |
| 3 | TimTec | 143431076 | SBB056562 |
| 37 | VladaChem | 381009696 | VL264710-100G |
| 54 | Win-Win Chemical | 438495889 | 1008 |
| 58 | Yuhao Chemical | 347739804 | RT12304 |
| 58 | Yuhao Chemical | 463761116 | LL0468 |